Animal hoarding: a systematic review

Objectives: Animal hoarding is a special manifestation of hoarding disorder, characterized by the accumulation of animals and failure to provide them with minimal care. The main objective of this systematic review is to evaluate the characteristics of animal hoarding, focusing on the profile of affected individuals and the features of accumulation behavior. Methods: A systematic search of the literature was conducted in the electronic databases MEDLINE, Scopus, and LILACS until October 2022. We included case series (n ≥ 10) and cross-sectional studies assessing animal hoarding. Results: A total of 374 studies were initially retrieved. Most studies were classified as having poor quality and significant risk of bias. A total of 538 individuals with animal hoarding were evaluated. These individuals were predominantly middle-aged, unmarried women who lived alone in urban areas. Most of their residences had unsanitary conditions. Recidivism rates varied from 13-41%. Cats and dogs were the main hoarded species, mostly acquired through unplanned breeding, and disease, injury, behavioral problems, and a lack of hygiene were characreristic of their condition. Animal carcasses were found in up to 60% of the properties. Conclusion: Animal hoarding is a complex condition that requires urgent attention. More research is necessary to develop effective strategies that can save community resources, improve animal and human welfare, and prevent recidivism.

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

Kraepelin's views on obsessive neurosis: a comparison with DSM-5 criteria for obsessive-compulsive disorder

Emil Kraepelin (1856-1926) is considered one of the founders of modern psychiatric nosology. However, his conceptualization of obsessive-compulsive phenomena is relatively understudied. In this article, we compare and contrast excerpts from the eighth edition (1909-1915) of Kraepelin's Textbook of Clinical Psychiatry focusing on what Kraepelin called "obsessive neurosis" and related "original pathological conditions" with the current DSM-5 criteria for obsessive-compulsive disorder (OCD). Consistently with DSM-5 OCD, Kraepelin described obsessive neurosis as characterized by obsessive ideas, compulsive acts, or both together. His detailed descriptions of these symptoms are broadly coherent with their characterization in DSM-5, which is also true for the differential diagnoses he provided. He also mentioned cases illustrating decreased insight into symptoms and association with tic disorders. In conclusion, Kraepelin's experience, which reflects decades of consistent clinical work, may help validate current ideas and explain how the current conceptualization has emerged and developed. Even though one can hardly say that the classification laid out in DSM-5 goes back to Kraepelin's views directly, it still is true that Kraepelin played an outstanding role in systematizing psychiatric diagnostic criteria in general, and provided a major contribution to the conceptual history of OCD.

Hoarding disorder: a new diagnostic category in ICD-11?

Despite the long-held view that hoarding is a symptom of both obsessive-compulsive disorder and obsessive-compulsive personality disorder, increased evidence has emerged during the last 20 years suggesting that hoarding represents a distinct form of psychopathology. This study reflects the discussions on the nosological status of hoarding carried out by the WHO ICD-11 Working Group on the Classification of Obsessive-Compulsive and Related Disorders. The distinctiveness of hoarding is based on its having core symptoms that differ from those of other disorders, as well as distinctive neurobiological correlates and treatment responses. Furthermore, data showing the clinical utility, global applicability, and appropriateness of the concept of hoarding disorder outside specialty mental health settings suggest that this condition should be included in ICD-11. Finally, given the focus of ICD-11 on primary care and public health, the Working Group suggests that poor insight and severe domestic squalor may be considered as specifiers for hoarding disorder in ICD-11.

A review on predictors of treatment outcome in social anxiety disorder / Uma revisão sobre fatores de predição de resposta ao tratamento no transtorno de ansiedade social

OBJECTIVE: This article aims to review the clinical features and therapeutic characteristics that may predict treatment response in patients with social anxiety disorder (SAD). METHODS: A systematic review of trials identified through databases of ISI, Medline, PsycInfo, Cochrane, LILACS, Current Controlled Trials, and in references of previously selected articles published in English up to December 2010. In our literature search, we used the words prediction/predictors and social anxiety disorder or social phobia. RESULTS: Early onset, greater disease severity, comorbidity with other anxiety disorders (including generalized anxiety disorder and simple phobia), and high expectations about the role of the therapist emerged as potential predictors of less effective treatment in SAD. CONCLUSIONS: Knowledge of various clinical and treatment features may help professionals to predict possible responses to therapeutic interventions in patients with SAD. However, given the diversity of measures used to assess response, further studies should be performed with standardized methods to investigate the aspects related to treatment resistance in SAD.

OBJETIVO: Este artigo tem por objetivo descrever as principais características clínicas e terapêuticas que possam predizer resposta ao tratamento em pacientes com transtorno de ansiedade social (TAS). MÉTODOS: Revisão sistemática de ensaios clínicos identificados através das bases de dados ISI, Medline, PsycInfo, Cochrane, LILACS, Current Controlled Trials e em referências bibliográficas de artigos previamente selecionados publicados em inglês até dezembro de 2010. As seguintes palavras-chave foram utilizadas em nossa busca bibliográfica: prediction/predictors e social anxiety disorder ou social phobia. RESULTADOS: Início precoce, maior gravidade da doença, comorbidade com outros transtornos de ansiedade (incluindo o transtorno de ansiedade generalizada e fobia simples) e alta expectativa sobre o papel do terapeuta emergiram como potenciais fatores de predição menor eficácia do tratamento do TAS. CONCLUSÕES: O conhecimento de uma variedade de características clínicas e de tratamento pode auxiliar os profissionais a preverem possíveis respostas às intervenções terapêuticas nos pacientes com TAS. No entanto, devido à diversidade de medidas utilizadas para avaliar a resposta, novos estudos com o objetivo de investigar aspectos relacionados à resistência ao tratamento do TAS devem ser realizados com métodos mais padronizados.

Transtorno de estresse pós-traumático de início tardio? Reflexões diagnósticas baseadas em um relato de caso / Delayed-onset post-traumatic stress disorder? Diagnostic reflections on a case report

OBJETIVO: Neste estudo, o objetivo foi relatar o caso de uma paciente com transtorno de estresse pós-traumático (TEPT) de início aparentemente tardio e os diferentes dilemas surgidos durante seu diagnóstico. MÉTODO: Relato de caso. RESULTADOS: Paciente feminina, de 34 anos, casada e do lar, apresentou TEPT 25 anos após o desabamento de sua residência durante uma enchente. O quadro surgiu após relatos na imprensa de eventos semelhantes associados ao soterramento de dezenas de vítimas em um município vizinho. CONCLUSÃO: Este caso sugere que pacientes podem desenvolver quadros semelhantes ao TEPT de início tardio após a reexposição a eventos previamente desprovidos de impacto emocional.

OBJECTIVE: In this study, our objective was to report a patient with an apparent diagnosis of delayed-onset posttraumatic stress disorder (PTSD) and the different dilemmas faced during the diagnostic process. METHOD: Case report. RESULTS: A female patient, aged 34, married, housewife, presented PTSD 25 years after the collapse of her home during a flooding. The condition emerged after press reports of similar events associated with the death of dozens of victims in a nearby town. CONCLUSION: Our case suggests that patients may develop conditions that bear resemblance to late-onset PTSD after re-exposure to events previously devoid of emotional impact.

O teste de associação implícita no transtorno obsessivo-compulsivo (TAI-TOC): consistência interna e correlações com medidas explícitas / The implicit association test in obsessive-compulsive disorder (IAT-OCD): internal consistency and correlation with explicit assessments

CONTEXTO: Avaliações tradicionais de sintomas obsessivo-compulsivos, baseadas na introspecção, estão sujeitas a diversas variáveis, como os níveis de insight apresentados pelo paciente. OBJETIVOS: Neste estudo, nosso objetivo foi o de avaliar a consistência interna e as correlações clínicas de um teste que busca identificar a existência de um viés cognitivo implícito em pacientes com transtorno obsessivo-compulsivo (TOC). MÉTODOS: Quarenta pacientes com TOC realizaram o teste de associação implícita para o TOC (TAI-TOC) e responderam a três instrumentos de autoavaliação [Inventário de Ansiedade de Beck (BAI), Inventário de Depressão de Beck (BDI), Inventário de Obsessões e Compulsões - Revisado (OCI-R)]. RESULTADOS: O valor do alfa de Cronbach com itens de treino foi de 0,83 e sem o treino foi de 0,79. Não foram observadas correlações significativas entre os escores gerados pelo TAI-TOC e os instrumentos de autoavaliação, i.e., BDI, BAI e diferentes dimensões do OCI-R. CONCLUSÃO: Nossos achados apontam para uma elevada consistência interna do TAI-TOC. A ausência de correlações entre o TAI-TOC e diferentes dimensões do OCI-R sugere que medidas implícitas e explícitas de sintomas obsessivo-compulsivos podem formar constructos independentes. Estudos futuros, com maior número de pacientes, são necessários para confirmar essa hipótese.

BACKGROUND: Traditional assessments of obsessive-compulsive symptoms, based on patients' introspection, are subject to several factors, including the levels of insight presented by them. OBJECTIVES: In this study, our goal was to assess the internal consistency and clinical correlations of a test that seeks to identify the existence of an implicit cognitive bias in patients with obsessive-compulsive disorder (OCD). METHODS: 40 patients with OCD performed the implicit association test for OCD (IAT-OCD) and answered three instruments of self-assessment [Beck Anxiety Inventory (BAI), Inventory, Beck Depression Inventory (BDI), Obsessive-Compulsive Inventory-Revised (OCI-R)]. RESULTS: Cronbach's alpha with IAT-OCD training items was 0.83 and without them 0.79. There were no significant correlations between the IAT-OCD scores and the instruments of self-assessment, e.g., BDI, BAI and different dimensions of the OCI-R. DISCUSSION: Our findings are consistent with a high internal consistency of the IAT-OCD. The absence of correlations between the IAT-OCD and different dimensions of the OCI-R suggests that implicit and explicit measures of obsessive-compulsive symptoms may be independent constructs. Future studies, with greater number of patients, are needed to confirm this hypothesis.

Toxina botulínica como tratamento para fobia social generalizada com hiperidrose / Botulinum toxin as a treatment for social phobia with hyperidrosis

CONTEXTO: Enrubescimento, tremores e transpiração excessiva são fenômenos frequentemente observados na fobia social. OBJETIVOS: Descrever a resposta de um paciente com o tipo generalizado de fobia social e hiperidrose à terapia cognitivo-comportamental aliada à toxina botulínica. MÉTODO: Relato de caso único. RESULTADOS: O Sr. A, 20 anos, estudante universitário, procurou tratamento por apresentar sintomas compatíveis com os diagnósticos de fobia social e depressão. O Sr. A também apresentava diagnóstico de hiperidrose palmar, plantar e axilar. Tanto a fobia social quanto a hiperidrose tiveram seu início no começo da adolescência, com a primeira se iniciando quatro anos antes da segunda. A terapia cognitivo-comportamental levou à remissão da depressão, mas o tratamento efetivo da fobia social apenas foi possível após a terapia com a toxina botulínica. CONCLUSÃO: A toxina botulínica, um tratamento que bloqueia fenômenos autonômicos periféricos, também pode proporcionar alívio dos sintomas em pacientes com fobia social.

BACKGROUND: Blushing, trembling, and sweating are frequently seen in social phobia. OBJECTIVES: In this study, we aimed at describing the response of a patient with a generalized type of social phobia and hyperhydrosis to cognitive-behavioral therapy augmented by botulinum toxin. METHOD: Single case report. RESULTS: Mr. A, a 20 year-old university student, sought treatment in our unit for social phobia with comorbid depression. Mr. A also exhibited a diagnosis of palmar, plantar, and axilar hyperidrosis. He described that exposure to feared situations always lead to aggravation of sweating and other symptoms of heightened physiological arousal. Both social phobia and hyperhydrosis had their onset in early adolescence, with the former beginning four years before the latter. Cognitive-behavioral therapy led to aliviation of depression but effective treatment of social phobia was only possible after therapy with botulinum toxin. DISCUSSION: Botulinum toxin, a treatment that blocks peripheral autonomic symptoms, might also lead to improvement of social phobia.

O conceito do insight em pacientes com transtorno obsessivo-compulsivo / The concept of insight in patients with obsessive-compulsive disorder

OBJETIVO: Atualizar os clínicos sobre a existência de um possível subtipo do transtorno obsessivo-compulsivo caracterizado por pouco insight. MÉTODO: Revisão opinativa baseada em estudos indexados na base de dados PubMed e PsychINFO, identificados por meio dos unitermos "obsessive-compulsive disorder" e "insight" ou "ego-dystonic" e publicados entre 1966 e outubro de 2009. Os resultados foram examinados de acordo com a estratégia utilizada para abordar o insight, i.e. categórica vs. dimensional. RESULTADOS: Análise dos estudos nos permitiu identificar pontos que colocam em dúvida a existência de um subtipo do transtorno obsessivo-compulsivo bem delimitado caracterizado por pouco insight. Estes pontos incluem 1) prevalência extremamente variável do transtorno obsessivo-compulsivo com insight reduzido encontrada em estudos categóricos, 2) homogeneidade dos achados fenotípicos (i.e. maior gravidade) associados a baixo insight em estudos categóricos e dimensionais e 3) ausência de estudos que investigam "zonas de raridade" entre as formas de transtorno obsessivo-compulsivo com pouco e bom insight. CONCLUSÃO: Embora uma abordagem categórica do insight no transtorno obsessivo-compulsivo seja importante em ambientes clínicos, uma vez que neles existem demandas prementes para tomada de decisões, a abordagem dimensional do insight parece refletir de forma mais fidedigna o fenômeno apresentado pelos pacientes em tela.

OBJECTIVE: To update clinicians regarding the existence of a putative subtype of obsessive-compulsive disorder based on poor insight. METHOD: Opinionative review based on studies indexed in the PubMed and PsychINFO databases, identified by means of the keywords "obsessive-compulsive disorder" AND "insight" OR "ego-syntonic", and published between 1966 and October 2009. The results were analyzed according to the approach adopted, i.e. a categorical or dimensional view of insight in obsessive-compulsive disorder. RESULTS: The review of recent studies led us to identify some issues that cast doubts over the existence of a clear-cut poor insight subtype of obsessive-compulsive disorder. These issues include 1) an extremely variable prevalence of poor insight obsessive-compulsive disorder in categorical studies, 2) a significant degree of homogeneity in the phenotypical findings (i.e. greater severity) associated with lower levels of insight in obsessive-compulsive disorder in both categorical and dimensional studies and, 3) a lack of studies investigating zones of rarity between poor and good insight obsessive-compulsive disorder. CONCLUSION: Although a categorical approach to the insight issue in obsessive-compulsive disorder is still important in clinical settings, where decision-making is often a critical issue, a dimensional approach seems to reflect levels of impairment in these patients more reliably.

A construção de um novo instrumento para avaliar correlatos implícitos dos sintomas do transtorno obsessivo-compulsivo: primeira versão do Teste de Associação Implícita / The construction of a new instrument to assess implicit correlates of obsessive-compulsive disorder symptoms: first version of the Implicit Association Test

CONTEXTO: A inexistência de uma medida implícita para sintomas do transtorno obsessivo-compulsivo (TOC) limita a avaliação às escalas e aos inventários tradicionais. OBJETIVOS: O objetivo foi construir um instrumento de avaliação de sintomas obsessivo-compulsivos que independa da autoavaliação pelo examinando [por exemplo, o Teste de Associação Implícita para transtorno obsessivo-compulsivo (TAI-TOC)]. MÉTODOS: A fim de construir o TAI-TOC, foram consultados (1) estudos anteriores que utilizaram o TAI para avaliação de outros sintomas psiquiátricos, (2) psiquiatras e psicólogos com experiência na avaliação e tratamento de pacientes com TOC e (3) os próprios pacientes com TOC. RESULTADOS: Estímulos verbais e visuais foram selecionados para cada dimensão dos sintomas obsessivo-compulsivos (contaminação e lavagem, obsessões de checagem, simetria e colecionismo). Um software projetado para mensurar o tempo de reação em milissegundos (um programa para associação implícita) foi desenvolvido. Uma versão final do TAI-TOC foi obtida. CONCLUSÕES: O TAI-TOC expande o arsenal existente para avaliação dos sintomas obsessivo-compulsivos, especialmente naqueles indivíduos que informam mal sobre seus sintomas.

BACKGROUND: The lack of an implicit measure for the obsessive-compulsive disorder symptoms limits its assessment to the traditional scales and inventories. OBJECTIVES: The aim is the construction of an instrument for the evaluation of obsessive-compulsive symptoms that is independent from examinee's self-evaluation [i.e. the Implicit Association Test for obsessive-compulsive disorder (IAT-OCD)]. METHODS: In order to build the IAT-OCD, we consulted (1) previous studies that employed the IAT for the evaluation of other psychiatric symptoms; (2) expert psychiatrists and psychologists with experience in the assessment and treatment of patients with OCD; and (3) patients with OCD themselves. RESULTS: Specific verbal and visual stimuli were selected for each obsessive-compulsive symptom dimensions (contamination-washing, obsessions-checking, symmetry and hoarding). A software designed to measure reaction time in miliseconds (a proxy for implicit association) was developed. A final version of the IAT-OCD was then obtained. DISCUSSION: The IAT-OCD expands the existing armamentarium to evaluate obsessive-compulsive symptoms, especially among those individuals who report badly about their symptoms.

Resistência ao tratamento nos transtornos de ansiedade: fobia social, transtorno de ansiedade generalizada e transtorno do pânico / Treatment-resistant anxiety disorders: social phobia, generalized anxiety disorder and panic disorder

OBJETIVOS: Os transtornos de ansiedade são condições psiquiátricas prevalentes que determinam importante prejuízo funcional, piora na qualidade de vida do indivíduo e um enorme custo social. Embora diversas medicações eficazes para os transtornos de ansiedade encontrem-se disponíveis, um número significativo de pacientes não responde adequadamente ao tratamento e muitos permanecem com sintomas residuais clinicamente significativos. O objetivo deste estudo é rever aspectos relacionados à resistência ao tratamento e estratégias farmacológicas no manejo dos transtornos de ansiedade resistentes ao tratamento. MÉTODO: Revisão narrativa. RESULTADOS: São discutidos os diversos aspectos conceituais relacionados à resistência ao tratamento, os possíveis preditores de resistência e, finalmente, algumas estratégias a serem utilizadas no manejo dos transtornos de ansiedade (incluindo transtorno de ansiedade social, transtorno de ansiedade generalizada e transtorno do pânico) que não respondem às abordagens terapêuticas convencionais. CONCLUSÃO: A resistência ao tratamento ainda é um desafio para a prática clínica que começa em conceitos não operacionalizados de resposta e resistência e termina na escassez de estudos controlados sobre estratégias de tratamento nesse último cenário clínico.

OBJECTIVES: Anxiety disorders are common psychiatric conditions that cause significant disability, poor quality of life and enormous social cost. Although treatments with demonstrable efficacy are available a great number of patients fail to respond or remains with clinically significant residual symptoms after treatment. The objective of this study is to review aspects related to treatment resistance and pharmacological strategies to deal with anxiety disorders resistant to treatment. METHOD: Narrative review. RESULTS: We discuss conceptual aspects related to treatment resistance or refractoriness, predictors of poor treatment outcome, and finally, some strategies to deal with anxiety disorders (including social anxiety disorder, generalized anxiety disorder and panic disorder) that do not respond to standard therapeutic interventions. CONCLUSION: Treatment resistance in anxiety disorders remains a challenge to clinical practice going from non standardized concepts of response and resistance to a paucity of controlled studies concerning therapeutic strategies.

Antipsicóticos, anticonvulsivantes, antiadrenérgicos e outras drogas: o que fazer quando o transtorno do estresse pós-traumático não responde aos inibidores seletivos da recaptação da serotonina? / Antipsychotics, anticonvulsants, antiadrenergics and other drugs: what to do when posttraumatic stress disorder does not respond to selective serotonin reuptake inhibitors?

OBJETIVOS: Nesta revisão narrativa, o objetivo foi descrever as opções farmacológicas para o tratamento do transtorno de estresse pós-traumático nos casos de intolerância, resistência, refratariedade ou impossibilidade de utilizar antidepressivos, especialmente inibidores seletivos da recaptação da serotonina. MÉTODO: Consulta às bases de dados ISI Web of Science e PubMed em busca de estudos originais sobre o tratamento farmacológico do transtorno de estresse pós-traumático em diferentes cenários clínicos. RESULTADOS: Evidências preliminares apontam para a utilidade de drogas como a risperidona, a olanzapina, a lamotrigina e o prazosin como estratégias para o cenário clínico em tela. A escolha do medicamento de segunda linha deve levar em conta não só os sintomas, como também as comorbidades, os tratamentos prévios, as interações farmacológicas, os efeitos colaterais e as condições físicas do paciente. CONCLUSÕES: Futuros ensaios clínicos randomizados ainda são necessários para estabelecer com clareza alternativas farmacológicas aos antidepressivos para o tratamento do transtorno de estresse pós-traumático.

OBJECTIVES: In this narrative review, we aimed to describe different pharmacological strategies for the treatment of patients with post-traumatic stress disorder who display different levels of intolerance, resistance, refractoriness, or who are unable to take to antidepressants, especially serotonin reuptake inhibitors. METHOD: We searched the ISI web of science and the PubMed for original studies focusing in the treatment of PTSD in different clinical scenarios. RESULTS: Preliminary evidence pointed towards the efficacy of drugs such as risperidone, olanzapine, lamotrigine and prazosin as strategies to be employed in the above mentioned clinical scenarios. The choice of a specific "second line" drug should take into account not only symptoms, but also pattern of comorbidities, previous response to other treatments, pharmacological interactions, side-effects, and patient's physical conditions. CONCLUSIONS: Future randomized controlled trials should be performed in order to unveil which drugs should be prescribed in the absence of adequate treatment and response to serotonin reuptake inhibitors.